WASHINGTON - The US Treasury Department on Thursday targeted the assets of Griselda Lopez Perez, second wife of fugitive drug baron Joaquin "Shorty" Guzman, stepping up pressure on the family of Mexico's most-wanted man who escaped from prison more than 11 years ago.

The action, which freezes any assets that she has under US jurisdiction and bans US citizens or firms from doing business with her, is the third such designation by the United States in five months of Guzman family members.

"This action builds on Treasury's aggressive efforts, alongside its law enforcement partners, to target individuals who facilitate ... Guzman's drug-trafficking operations," Treasury's Adam Szubin said in a statement.

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