IDF official: 3 months after Gaza war, Hamas still rehabilitating military hierarchy
EU Representative: Time running short on Gaza reconstruction
Netanyahu: There is an effort to undermine the Jews' right to their own state
South Africa's Zuma welcomes Abbas, says Israeli settlements undermining 2-state solution
Aharonovitch: It seems Arami's death was a terror attack
Green groups demand environment minister
What’s important is to stay on the wheel, Rivlin tells Czech Prime Minister
MK Regev: Plastic bag ban bill will not pass in its current form
Netanyahu-Rivlin spat on ‘Jewish state bill’ may put off early elections
Hookah smokers are inhaling benzene
Effective drugs for carriers of hepatitis C not included in health basket
Mild blows may cause major head injuries
Sharp rise in additional, private health insurance costs
Tech Talk: The best keyboard apps available for smartphones
Elbit Systems developing bus with supercapacitator fast-charging system
Zion Tech: Israeli start up Dogiz helps dogs and owners socialize
Zion Tech: Our Israeli start-up of the week aims to make air pollution visible
5th annual Hullegeb Festival celebrates Ethiopian culture
A man of leisure
Slovakian Tour de France star leads Israel’s first pro cycling team
Grapevine: Anniversary of the passing of founding PM David Ben-Gurion
Sinai Says: Matters go from bad to worse at fallen giant Maccabi Haifa
It’s now or never for Hapoel Jerusalem
Home-grown Israeli baseball: From youth to the pros
Ness Ziona keeps rolling with tough win over Nahariya
Finance C'tee members spar over Tel Aviv 'Nakba film festival'
Edelstein tells police chief not to stop MKs from ascending Temple Mount
US haredim seek to share kollels’ ‘burden’
Polish town plans to turn Jewish cemetery into apartment complex
Divided US Jews largely silent on ‘Jewish state bill’
South African court bans BDS protests inside Woolworths
Shoes of prisoners stolen from Majdanek Nazi death Camp
ISIS says its flag will wave over Jerusalem, even if the Jews don't like it
Iranian Police: 200,000 people in the country are alcoholics
WATCH: Syrian child preacher says stop chasing half-naked women, look to your 72 virgins
Pope: Don't close door on dialogue with Islamic State
Turkish governor apologizes to Chief Rabbi for saying synagogue would be turned into museum
‘But is it good for the Jews?’
New opportunities for Israel in Europe
We aren't crying wolf
Media Comment: The double whammy
Cinema of reconciliation
On the volcano’s edge
Knowledge, power and abuse
Q&A with a Colombian lone soldier
European Press: Dividing line
Veterans: Keeping an ear out for change
Book Review: Written from his heart
This Week in Jerusalem
Who is your God?
Grapevine: Amazing place
A voice from India
Happily Eva After: When the going gets tough...
Grapevine: Reclaiming our heritage
Upscale dining in Neveh Tzedek
Obama: Helping terror go nuclear
On incitement, lots of talk but little action
To finally look behind the news
Recognizing Palestine – anomalies and ambiguities
A song for Cheshvan: 'The Eucalyptus Grove'
הָאַרְכִיוֹן שֶל רוֹמַן וִישְנִיָאק
Har Nof in flames
WATCH: Get-Taxi gets Jewish, with 'Shlep'
Putting children first
Genome of lowly centipede sequenced, adding a piece to puzzle of how life started on Earth
A creative twist on Italian in the heart of Tel Aviv
'Game of Thrones', 'Breaking Bad' director MacLaren to oversee Gal Gadot in 'Wonder Woman'
Tempête au sein de la coalition
Crise de confiance
Qui prendra la relève de Mahmoud Abbas ?
Arafat, Abbas, même combat ?
Rétrospective en noir et blanc pour la ville d’Or
L’unité : notre seule planche de salut
Daniel Oren, maestro d’Israël, d’Italie et d’ailleurs !
Nos plus belles années ?
Le pot de chocolat liégeois par qui le scandale arrive
Le dernier kibboutz
La course aux étoiles
Les mordus du français
On n’invite pas un pyromane à éteindre un incendie
Tuer l’EI dans l’œuf
Le mont du Temple et la guerre sainte de l’islam
Les attentats du lundi 10 novembre vus par la presse française
L’Europe, nouvelle alliée d’Abbas ?
Christian priest speaks out strongly in favor of Jewish state law
Hispanic Evangelicals among Israel's greatest supporters
Christians United for Israel Chairman John Hagee says Obama is anti-Semitic
Temple Mount: Common ground between Jews and Christians
Pope Francis condemns Palestinian violence
KKL Belgium Donates Portable Bomb Shelter to Kiryat Gat
KKL-JNF Awards 2014 Blumberg Prize
Exploring the Ilanot Botanical Garden and the Vickar Observation Point
Cornerstone Laid for Sports Rehab Park at Meir Hospital
Mexican Politician and Business Leader Miguel Aleman Velasco Visits KKL-JNF in Jerusalem
International Conference in Sde Boker: Combating Desertification Together
Rehabilitation of the Lower Jordan: Bringing the River Back to Life
Central America Celebrates Independence at the Rabin Center
In his Footsteps: Heritage Excursions in Memory of Yitzhak Rabin
Cleanup Day Activities in Central Israel
International Cleanup Day: Cleaning Together in Northern Israel
KKL-JNF's Eyes in the Forest - The Horshim Forest Green Patrol
Israel Today and Tomorrow: KKL France Mission Visits Israel
Start-up Israel: KKL Italy November Mission Learns about Israel's Past and Future
KKL-JNF and Desert Agriculture Latin American Diplomats visit the Negev
A Successful Annual Fundraising Event for KKL Milan
Living Green in Israel: the Contest and the Winners
Addressing Climate Change Conference
Nurturing the Foresters of the Future
Saving the Sabras
11.26.2014 | 4 Kislev, 5775
Weizmann scientists bring nature back to artificially selected lab mice
Health Scan: The ‘memory’ of starvation is in the genes
Looking young in old age
Medical Corps training, improved technologies saved lives in Gaza
German ‘reneges’ on optional fluoridation of drinking water
Ministry urges taking preventive measures against West Nile virus
Religious Zionists, ultra-Orthodox men free to pursue nursing degree
*Health Scan: Upgrading the stethoscope*
*Danger: Viruses may trump mankind*
MDA urges adherence to safety rules to prevent drowning
Health Ministry instructs public hospitals to return to routine
*Rx for Readers: Is alarmist ad campaign’s vaccine as necessary as its sponsors say?*
Health & Science
JUDY SIEGEL-ITZKOVICH \
Medicine pills drugs prescription 311.
Type 2 diabetes is so common around the world that pharmaceutical companies are very keen to develop the optimal orally-administered drug, that would earn them major profits. A variety of medications for the condition are now in the pipeline, but they have to be carefully studied before being put on the market.One of the latest – examined by an Israeli-led international outcome study – is saxagliptin (known commercially as Onglyza). The US Food and Drug Administration (FDA) requested the outcome trials to approve the cardiovascular safety of the drug.One of the largest studies on saxagliptin, a new drug from the incretin family, was led by researchers from Hadassah University Medical Center in Jerusalem and the TIMI study group. The researchers just released results finding no excess risk for heart attack from the pill, but also noted that there was also no reduction in the risk for heart attack and an unexpected increase in hospitalization for heart failure.“Few diabetes drugs have been studied as thoroughly as saxagliptin,” said study co-principal investigator Prof. Itamar Raz, head of the diabetes unit at the Ein Kerem hospital. “This type of trial sets new standards for FDA-required drug safety studies.”“Patients under saxagliptin had better blood glucose control, a reduced need for insulin and a beneficial effect on the kidney, while hypoglycemia was more frequent. Other side effects suspected of being related to this class [of drugs] – such as pancreatitis – were not found,” said Raz.“We hope these findings will help to guide physicians and improve their ability to prescribe different diabetes drugs in a more evidence-based and datadriven way,” said study co-principal investigator Dr. Deepak Bhatt from the VA Boston Healthcare System and the TIMI study group of the cardiovascular division and Brigham and Women’s Hospital and Harvard Medical School.The Saxagliptin Assessment of Vascular Outcomes Recorded in Patients with Diabetes Mellitus (SAVOR-TIMI 53) trial was designed to determine the effect of the diabetes drug saxagliptin, a selective dipeptidyl peptidase 4 (DPP-4) inhibitor, on cardiovascular outcome. This large, double-blind, placebo-controlled international study was conducted at 788 sites in 26 countries and included 16,492 patients with type 2 diabetes who were randomized to receive either saxagliptin or matching placebo over a median of 2.1 years of follow-up.Treatment with all other diabetes and cardiovascular medications was left to the discretion of the treating physician.The primary endpoint, which was a composite of cardiovascular death, nonfatal heart attack or non-fatal ischemic stroke, was similar in intervention and control groups. Researchers also report that the secondary endpoint of cardiovascular death, myocardial infarction, stroke, or hospitalization for unstable angina, coronary revascularization or heart failure occurred in 12.8 percent of patients who received saxagliptin group compared to 12.4% in the placebo group.These results were presented at the European Society Cardiology 2013 Congress in Amsterdam and published simultaneously in the New England Journal of Medicine.
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