After polls closed in the Kansas Republican caucuses, NBC News and CNN projected Republican presidential candidate Ted Cruz as the winner.
In the Sunflower State, Republican frontrunner Donald Trump had sought to extend his lead in his quest for the 2016 Republican presidential nomination.
Republicans and Democrats went to the polls in five states on Saturday as the presidential nominating contest picks up steam.
Trump, the brash New York billionaire who has opened a substantial lead in delegates over presidential rivals, hopes to rack up more wins in Republican contests in Kansas, Kentucky, Louisiana and Maine.
Poll workers in Wichita counted ballots, and early reports has said that Texas Senator Ted Cruz has a substantial lead over Trump in Kansas.
Polling has been scarce in all four states, which together account for just 155 delegates, and the contests are open only to registered Republicans. The exclusion of the independent voters who have helped Trump's surge adds an air of uncertainty to the latest round of state-by-state contests to pick nominees for the Nov. 8 election to succeed President Barack Obama.
Since winning seven of 11 contests on Super Tuesday, Trump has come under withering fire from a Republican establishment worried he will lead the party to a resounding defeat in November's election.