‘WHO advisers on swine flu worked for drug companies’

Billions of dollars of antiviral drugs were stockpiled and not used.

By
June 6, 2010 05:35
4 minute read.
Israeli doctor examines swine flu patient.

Swine flu patient . (photo credit: Ariel Jerzolomiski)

 
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Key scientists advising the World Health Organization on planning for a swine flu (h1N1) pandemic had done paid work for pharmaceutical firms that stood to gain from the guidance these scientists were preparing, a joint investigation by the BMJ (British Medical Journal) and the Bureau of Investigative Journalism revealed on Friday.

A year ago, the WHO, an agency of the UN, coordinated the actions of governments around the world to fight H1N1, declared the new strain of swine-origin H1N1 as a pandemic, encouraging vaccination and giving daily press conferences. Its advice induced governments around the world to stockpile billions of dollars of antiviral drugs. Yet these conflicts of interest have not been publicly disclosed by the WHO, the British Medical Journal//Bureau of Investigative Journalism probe said. Despite repeated requests, the WHO “has failed to provide any details about whether such conflicts were declared by the relevant experts and what, if anything, was done about them,” the authors said.

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Israel’s Health Ministry followed the WHO’s recommendations, with Prime Minister and formal Health Minister Binyamin Netanyahu ordering the purchase of 7 million doses of vaccine and enough antiviral medications to cover the entire population at a cost of about half a million shekels. However, most of these were left unused because most Israelis declined to be vaccinated, and the H1N1 complications were mild enough in most people to make the antivirals unnecessary. No comment was available over the weekend from senior ministry officials who were involved in handling the H1N1 pandemic.

The new report echoes a highly critical inquiry by the Council of Europe, whose findings were also published on Friday and fueled suspicions that the drug industry was able to exert undue influence on the WHO’s decisions about the swine flu pandemic and the mass stockpiling of drugs.

The investigation found that the WHO’s 2004 guidance on the use of antivirals in a pandemic was prepared by an influenza expert who had received payment from the Basel-based Hoffmann–La Roche, manufacturers of oseltamivir (Tamiflu), and the London-based GlaxoSmithKline, manufacturers of zanamivir (Relenza), for lecturing and consultancy work. The guidance concluded that “countries should consider developing plans for ensuring the availability of antivirals” and that they “will need to stockpile in advance, given that current supplies are very limited.”

In addition, the investigation found two other scientists who prepared annexes to the WHO 2004 pandemic guidelines had recent financial links to Roche. Authors Deborah Cohen of the British Medical Journal and Philip Carter of the Bureau of Investigative Journalism maintained that the WHO “did not publicly disclose any of these conflicts of interest when it published the 2004 guidance. It is not clear whether these conflicts were notified privately by WHO to governments around the world, many of which followed its advice.”

This “lack of transparency,” they continued, “is compounded by the existence of a secret ‘emergency committee’ that advised WHO’s director-general Margaret Chan on declaring an influenza pandemic. Significantly, the names of the 16 committee members are known only to people within WHO, and as such their possible conflicts of interest with drug companies are unknown.”



The WHO has denied that any industry influenced the scientific advice it received. It also says it takes conflicts of interests seriously and has the mechanisms in place to deal with them. But the British Medical Journal and the Bureau suggest that WHO seems not to have followed its own rules for the decision-making around the pandemic.

“And, despite repeated requests, the WHO has refused to provide any information about the conflict of interest declarations made to it, leaving the investigation to wonder whether major public health organizations are able to manage the conflicts of interest that are inherent in medical science effectively,” the joint report stated.

Cohen and Carter wrote that the WHO’s response to criticism “is also disappointing, given WHO’s track record of standing up to industry. In the late 1970s, WHO sparked two iconic clashes with multinational companies over the marketing of breast milk substitutes in the developing world and the setting up of the Essential Drugs Programme. Both issues set WHO at loggerheads with the US, where these industries had major holdings. Partly in response to WHO’s position, America withdrew contributions to WHO’s budget.”

In an accompanying editorial, British Medical Journal editor-in-chief Dr Fiona Godlee wrote that “the WHO’s credibility has been badly damaged” and that recovery will be fastest if it “publishes its own report without delay or defensive comment, makes public the membership and conflicts of interest of its emergency committee and develops, commits to, and monitors stricter rules of engagement with industry that keep commercial influence away from its decision-making.”

On the basis of their own investigation and those of others, they said the answer to the question about what to do about conflicts “is now inescapable... No one should be on a committee developing guidelines if they have links to companies that either produce a product – vaccine or drug – or a medical device or test for a disease. The same, and more, must apply to committees making major decisions on public health. Where entirely independent experts are hard to find, experts who are involved with industry could be consulted but should be excluded from decision-making. The US has made important progress with its Sunshine Act and other legislation. European legislation on managing conflicts of interest is long overdue,” Cohen and Carter concluded in their paper.

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