IAF aircraft early Friday struck the Palestinian Interior Ministry, Palestinian witnesses said, setting it on fire.
No one was hurt. The IDF confirmed its planes hit the office of Interior Minister Said Siyam, which it called "a meeting place to plan and direct terror activity."
The Interior Ministry is nominally in charge of Palestinian security forces, though Palestinian Authority President Mahmoud Abbas removed most of its authority.
Smoke rose from the building in downtown Gaza City, empty because of the late hour. The air strike took place around 1:30 a.m. Friday (2230 GMT Thursday).