Vice President Joe Biden at the annual conference for J Street on Monday said a nuclear armed Iran was an unacceptable danger but that the US was willing to give diplomacy a chance.

"A nuclear armed Iran would pose an existential threat to Israel, an unacceptable danger to world peace and security, including the likelyhood of a nuclear arms race in the Middle East, making everyone less secure," Biden said.

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"We don't know if Iran is willing to do what is necessary to get there, but we, along with the Security Council and Germany (P5+1) are willing to find out," Biden said.

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