Three people were killed and 25 injured on Sunday in a 75-vehicle pile-up along a fog-shrouded stretch of Virginia highway, local media reports and the state's department of transportation said.

The accident occurred at about 1:15 p.m. in the Fancy Gap Mountain area of Virginia, shutting down Interstate 77 in both directions, the Virginia Department of Transportation said.

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It said the accident backed up traffic for eight miles.

Police said heavy fog was to blame for the accident.