Two Israelis were injured on Saturday just moments after a Palestinian rocket slammed into a home in the Gaza frontier town of Netivot.
The injuries, which are not considered serious, occurred as they were running toward bombproof shelters.
The IDF retaliated by killing the Palestinians who launched the rockets toward Netivot.
Palestinians in the Gaza Strip resumed rocket fire at Israel on Saturday, the fifth day of Operation Protective Edge.
After a relatively quiet overnight, Israelis in the western Negev, Ashkelon, Ashdod, and the Shfela region awoke to the sounds of sirens. Most of the 50 or so rockets fell in uninhabited areas, while media reports indicate at least one rocket was intercepted by Iron Dome.
The Iron Dome anti-rocket system intercepted a rocket over Rehovot, while others fell in open areas near the city. There were no reports of damage or injuries.
The renewed barrage comes one day after two Israelis were lightly injured when a Palestinian rocket struck a home in Beersheba. One of the injured, an 80-year-old woman, was rushed to Soroka Medical Center.
An hour earlier, the Iron Dome battery intercepted two rockets over Tel Aviv and at least two rockets over Herzliya on Friday evening just seconds after sirens were heard across the region.
Earlier in the day, the anti-missile system intercepted dozens of Palestinian rockets fired at suburban Tel Aviv, the Shfela region, Beersheba, and the western Negev, which was the hardest hit.
Since hostilities were renewed, Hamas and Islamic Jihad operatives have launched nearly 700 rockets at Israeli towns.