ST PETERSBURG, Russia - Russia and the United States still have differences over the how to resolve the conflict in Syria following talks on Friday, a senior US State Department official said.

"There are still areas of difficulty and difference," the official said after US Secretary of State Hillary Clinton and Russian Foreign Minister Sergei Lavrov met in St Petersburg on the eve of international crisis talks on Syria in Geneva.

The official confirmed Clinton and Lavrov still intended to attend Saturday's meeting with the other countries that are permanent members of the UN Security Council. "We may get there (on an agreement) tomorrow, we may not," the official said.

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