Pensioners' Affairs Minister Uri Orbach took leave from his position on Sunday, as his health continued to deteriorate.
Orbach was hospitalized a month ago at Jerusalem's Shaare Zedek Medical Central for treatment of a hematological (blood) disease from which he suffers.
Economy Minister Naftali Bennett will take over Orbach's responsibilities as he continues treatment.
A prayer rally will be held in Orbach's hometown Modi'in on Sunday night.
Two weeks ago, Bennett asked on his Facebook wall for the public to pray for his "beloved friend who is dear to me like a brother," Uri Shraga son of Pnina, and Orbach took to the social network to thank the public for their prayers.
Orbach came in fourth in the Bayit Yehudi primary, and is sixth on the party's list for Knesset.