TAU Professor Yosef Shiloh 311.
(photo credit: Ayelet Kelertag/TAU)
Prof. Yosef Shiloh of Tel Aviv University Sackler Medical School has become the
first Israeli researcher ever to receive the prestigious Clowes Memorial Award
from the American Association for Cancer Research, it was announced on
The AACR is regarded as the world’s largest and most important
organization in the field.
AACR was founded in 1907 by a group of 11
physicians and scientists interested in research, to further the investigation
and spread knowledge of cancer.
Today it targets the prevention and cure
of cancer by promoting research, education, communication, and
The Clowes Memorial Award was established by the Eli Lilly
and Company in 1961 to honor Dr. G.H.A. Clowes, a founding member of the AACR
and a research director of the pharmaceutical company. The Clowes Award, which
comes with a $10,000 prize, recognizes an individual with outstanding recent
accomplishments in basic cancer research.
Shilo, who with his TAU team
has devoted himself to the study of the DNA damage response and the human
genetic disorder ataxia-telangiectasia (A-T), in which a central axis of the DNA
damage response is missing, will deliver a lecture during AACR’s annual meeting
in Orlando, Florida in April.
Shiloh notes that the DNA damage response
is the cornerstone of a sophisticated system that maintains the stability and
integrity of the cellular genome and is an intricate network of signaling
pathways that is rapidly activated following the induction of various DNA
lesions – most notably, one of the most dangerous ones: double strand
AACR director Margaret Foti said Shiloh’s work has launched a
“scientific revolution and opened up new horizons in the understanding of how
the living cell copes with DNA damage, which is among the main factors in
“Our great hope,” said Shiloh, “is to understand this complex
mechanism, and this will make it possible to design new treatments for cancer
and other diseases that result from the failure in protection from DNA damage.”