Hope for better osteoporosis drug after HU scientists’ find

Discovery by HU team of connection between bone density and fatty acids has led them to begin developing drug they hope will better treat osteoporosis.

October 5, 2010 04:57
2 minute read.
A elderly woman with osteoporosis

311_Osteoporosis. (photo credit: Courtesy)


Dear Reader,
As you can imagine, more people are reading The Jerusalem Post than ever before. Nevertheless, traditional business models are no longer sustainable and high-quality publications, like ours, are being forced to look for new ways to keep going. Unlike many other news organizations, we have not put up a paywall. We want to keep our journalism open and accessible and be able to keep providing you with news and analyses from the frontlines of Israel, the Middle East and the Jewish World.

As one of our loyal readers, we ask you to be our partner.

For $5 a month you will receive access to the following:

  • A user uxperience almost completely free of ads
  • Access to our Premium Section and our monthly magazine to learn Hebrew, Ivrit
  • Content from the award-winning Jerusalem Repor
  • A brand new ePaper featuring the daily newspaper as it appears in print in Israel

Help us grow and continue telling Israel’s story to the world.

Thank you,

Ronit Hasin-Hochman, CEO, Jerusalem Post Group
Yaakov Katz, Editor-in-Chief

UPGRADE YOUR JPOST EXPERIENCE FOR 5$ PER MONTH Show me later Don't show it again

The discovery by a Hebrew University of Jerusalem team of a connection between bone density and fatty acids has led them to begin developing a drug they hope will more effectively treat – and even prevent – the debilitating bone-thinning disease of osteoporosis.

Their paper has just been published in the Proceedings of the National Academy of Sciences, the official journal of the American academy.

Be the first to know - Join our Facebook page.

The research team is headed by Prof. Itai Bab of the university’s bone laboratory and Prof. Raphael Mechoulam of the Institute of Drug Research, who is a world-renowned expert on the active ingredients in cannabis. Other members include post-doctoral fellow Reem Smoum and doctoral students Gary Millman, Orr Ofek, Alon Bajayo, Joseph Tam, Vardit Kram and associates from the US.

Osteoporosis, the most widespread degenerative disease in the Western world, affects mostly women after menopause but also a minority of men. It causes the bones to be fragile from the loss of bone mass, leading to frequent bone fractures, disability and even death. The loss of bone mass in osteoporosis is caused by internal destruction of the bone tissue. With age, the quantity of bone tissue that is lost is greater than that which is created, which leads to the decrease in bone density.

Working on lab mice, the team discovered a group of substances – fatty acids and amino acids called “acyl amides” – in the body that play a key role in controlling bone density. They then analyzed their precise chemical composition, created synthetic versions of them and examined their effect on bone cell cultures.

In their lab experiments, they discovered that one of the compounds in the group of synthetic materials, oleoyl serine, increased bone density in both healthy mice and those with osteoporosis. They also found that the osteoporotic mice lacked oleoyl serine in their bones.

These findings, say the researchers, can serve as the basis for new drugs that may both prevent bone loss and boost bone formation and in this way reverse loss of bone tissue in osteoporosis patients.

Yissum, HU’s technology transfer company, has submitted a patent application based on their work and is seeking a commercial partner for further development.

Mechoulam felt certain that their work showing bone mass accumulation would lead soon to the development of an effective osteoporosis drug. Existing medications, such as biphosphonates, help either prevent further bone loss or encourage bone formation, but none of them is able to accomplish both functions together as this new formula can do, said Bab. In addition, some of the other drugs have unpleasant side effects.

The researchers noted that research in this field until now has been based primarily on proteins and genetics. Now, the Jerusalem researchers say, they have launched a new approach called “skeletal lipidomics” based on the examination of substances in the skeleton containing fatty acids and amino acids. This has great significance in understanding the regulation of metabolism in bone and in other body tissues, they said.

The research has been supported by the US-Israel Binational Science Foundation and a grant from the US National Institutes of Health.

Related Content

[illustrative photo]
September 24, 2011
Diabetes may significantly increase risk of dementia