A 50-seat commuter plane crashed into a home in suburban Buffalo on Thursday night, according to New York state police.
Fire officials said there were no survivors, and that it was unclear how many people were on the plane.
State Trooper John Manthey said the plane hit a house about 20 miles (32 kilometers) northeast of Buffalo around 10:10 p.m. (0310 GMT Friday) Thursday.
Flames erupted from remnants of the house and aircraft as firefighters sought to control the blaze.
Authorities said Continental Airlines Flight 3407 was operated by Manassas, Virginia-based Colgan Air. It was en route from Newark, New Jersey to Buffalo.