A number of suspects threw stones and Molotov cocktails at IDF soldiers who were guarding a road near the town of Efrat in Gush Etzion.
The soldiers chased the suspects into the town of El-Hader and were met with more stones and firebombs. The soldiers fired back and one Palestinian was hit, the IDF said.
He was initially treated by IDF medics and then evacuated by the Red Crescent, the IDF said.
The casualty was identified as 15-year-old Zaid Muhammad Ghunaim and died from his wounds, according to Palestinian media.