Israeli police fired stun grenades to disperse Palestinian worshipers who threw rocks at them after Friday prayers at the al-Aqsa Mosque compound on Temple Mount, Islam's third holiest site, a police spokesman said.
Dozens of officers entered the politically sensitive area in Jerusalem's Old City to break up hundreds of protesters, Israeli police spokesman Micky Rosenfeld said. He added that two policemen were slightly injured and 15 Palestinians arrested.
The mosque is part of a site revered by Jews as well as Muslims, and is a frequent source of friction. It was not immediately clear what prompted this clash in particular.
Israeli security forces had beefed up their presence in the area during the holiday of Rosh Hashanah, the Jewish new year, which began on Wednesday.