The deal, announced on Thursday, gives China access to Israel's high tech expertise, cachet among consumers made wary by domestic food production scandals and an alternative place to put their money amid trade obstacles from a wary United States.
Economy Ministry chief scientist Avi Hasson said the country was second last year after the United States in terms of joint projects between Israel and foreign firms backed by his office, which funds high tech start-ups and facilitates business abroad.
"In 2014 I think China will be number one," Hasson told Reuters. "Three years ago they were at zero."
Economy Minister Naftali Bennet said Israel was "going East", telling a high tech conference Asia had overtaken the US as Israel's second largest export destination after Europe. "We are shifting our economic resources to Bangalore, Africa and China, China, China," he said on Thursday.
Not everyone in Israel is delighted by the growing Chinese presence, and some argue their firms will have to pay more for direct investment than more sought-after Western or US brands.
"What normal country puts its food security and its entire milk industry in the hands of China?" opposition member of parliament Shelly Yachimovich said on Thursday.
Underscoring concerns of possible espionage, Israel's internal security agency Shin Bet last year advertised for fluent Chinese speakers to serve in the Tel Aviv area, and presumably keep an eye on growing numbers of Chinese visitors.
The economy ministry has played down the potential problems.
"One of the reasons that I assume people have concerns is that it's the unknown. China is still a riddle for many people," said Ohad Cohen, head of the Israeli Economy Ministry's foreign trade department.
Unlike in many other countries, there are no 'Chinatowns' in Israeli cities to serve as a bridge, but growing contacts and trade visits should improve mutual understanding and Israeli's welcome China's reluctance to get involved in the Middle East.
While China has become the manufacturing center of the world, it has not made such progress in innovation and technology. Israel, by comparison, lacks production muscle but prides itself on its high-tech inventiveness.
China says two-way trade has increased more than 200-fold in two decades, reaching more than $10.8 billion in 2013, making China Israel's third-largest trading partner after the European Union and the United States.
"The government of Israel has put the promotion of economic ties with China as a priority," said Cohen, pointing to visits to China over the past year by both Prime Minister Benjamin Netanyahu and President Shimon Peres.
Amir Gal-Or, Beijing-based managing partner of Israel-China investment firm Infinity, believes there will be a 20-30 percent annual rise in the number of Chinese acquisitions of Israeli firms in coming years, while investments in Israeli firms could double annually.
Earlier this week, Tel Aviv University and Tsinghua University of Beijing launched a $300 million joint center for innovative research and education, with Chinese Vice Premier Liu Yandong coming to Israel to mark the event.
"China has full confidence in the prospects for our relations," she told a Tel Aviv conference that attracted over 350 delegates from China. "We believe we have a lot to learn from Israel, which is well-known for its innovation."
At the same time, he said: "There's a void of investors in Israel. Israeli companies never get access to enough capital and don't raise nearly as much as their US counterparts."
But while Fisher expects Israeli venture capital firms to continue to raise money in China, he said direct Chinese investment in Israeli start-ups might be more difficult.
"It's not the same cachet as a US brand or even a European brand, so there will always be a tremendous discount on Chinese direct investments in Israeli companies," said Fisher, who has not raised money in China for his portfolio companies.
China's appearance on the Israeli financial stage started in earnest in late 2011, with the sale of 60 percent of generic agrochemical maker MA Industries - now called Adama - to China National Chemical Corp (ChemChina) for $1.44 billion.
The following year, Zohar Dayan, CEO of start-up Wibbitz, was scrolling through an email account he rarely checked when he came across a contact form filled out by Horizons Ventures, the venture capital firm of Hong Kong billionaire Li Ka-shing.
Dayan, like many in Israel's US-focused tech sector, was not familiar with Horizons at the time, but the email led to a $2 million investment in his firm, which has developed a technology that can turn text articles into short videos.
At a modern building in downtown Tel Aviv with views of the Mediterranean, high-tech firm ironSource in April received a Chinese delegation led by Xu Xiaoping, founder of the ZhenFund seed fund and New Oriental Education & Technology Group.
"We are seriously considering investing in a few Israeli companies," said Xu during his first visit to Israel. "The idea is to bring Israeli technology, innovation ... into the bigger Chinese market and develop the technology there."
The interest in Chinese investments is reciprocal."We are more active in seeking investments and China is now open, the awareness is there, we are on their radar," said Gidi Sturlesi, CEO of biosurgical products maker LifeBond, which expects to raise money from China by early next year.