Around 50 left-wing members of the "Bnei Avraham" group tried to dismantle the Giborim outpost near Hebron on Friday.
A group of 25 youths from the Kiryat Arba area came to stop them, Judea and Samaria Police reported.
Police forces arrived on the scene and separated the sides peacefully.
The IDF declared the area a closed military zone, and all the activists left except one left-wing objector.
He was arrested and taken to the Hebron police station for interrogation.