Syrian state news agency SANA initially reported the explosion, with local news source Deir Ezzor 24 reporting that the explosion was believed to have been caused by a mortar shell and that sirens were heard in the area.
A US defense official later told Reuters that US forces in the Conoco gas fields in eastern Syria took indirect fire on Saturday, but initial reports did not indicate any casualties or damage.
This incident is the latest in a recent round of attacks on US forces in Iraq and Syria.
US President Joe Biden ordered air strikes on pro-Iran militias in Syria in late June in response to a drone attack near Erbil that struck close to the site of the US consulate. The militias vowed to respond and fired a salvo at US forces in Syria near the Omar oil field.