Pompeo, who was former President Donald Trump's last secretary of state, served until Jan. 20, when Republican Trump left the office after being defeated by Democrat Joe Biden in the November election.
Pompeo and his wife asked a political appointee and other employees in his office to carry out tasks such as "picking up personal items, planning events unrelated to the Department's mission, and conducting such personal business as pet care and mailing personal Christmas cards," the State Department's Office of Inspector General (OIG) said in the report.
Among the incidents detailed in the report were a request from Susan Pompeo for an aide to make two hair salon appointments for her. On another occasion, an under secretary of state appeared to help the Pompeos' son secure a discount for a hotel room, the report said.
Pompeo during his tenure had a contentious relationship with the Department's watchdog. A former inspector general, Steve Linick, was fired by Trump at Pompeo's recommendation.
Linick was probing whether Pompeo misused a taxpayer-funded political appointee to perform personal tasks for himself and his wife.
OIG said it had completed most of its fieldwork on the report by August 2020. Its completion of the report was delayed because Pompeo refused to grant an interview to the OIG for several months until sitting down with them in December.
Representatives for Pompeo did not immediately respond to a request for comment. A counsel for Pompeo cited in the report described it as "replete with factual errors" and accused the drafters of apparent bias against Pompeo and his family.
A State Department spokesman said the agency concurred with "all the recommendations (in the report) and will proceed to implement them."