The common denominator of all kinds of cancer cells is damage to the genes’ normal DNA. Although it is already known that cell damage is caused by stress to their DNA replication when cancerous cells invade, the molecular basis remained unclear.But now, reportedly for the first time, Hebrew University scientists have shown that in early cancer development, cells suffer from insufficient building blocks to support normal DNA replication. It is possible to halt this by externally supplying the “building blocks,” resulting in reduced DNA damage and the cells’ significantly lower liklihood of developing cancerous features. Thus, it is hoped that eventually this will provide protection against cancer development.Prof. Batsheva Kerem of the Alexander Silberman Institute of Life Sciences and her Ph.D. student Assaf Bester showed that abnormal activation of cellular proliferation that drives many different cancer types leads to insufficient levels of the DNA building blocks (nucleotides) needed to support normal DNA replication.Then, using lab cultures to which cancerous cells were introduced, the researchers were able to show that through external supply of those DNA building blocks it is possible to reactivate normal DNA synthesis, thus negating the damage caused by the cancerous cells. This work, documented in the journal Cell, raises the possibility of new approaches for protection against precancerous development, even possibly creating a kind of treatment to decrease DNA breakage.CANCER SOCIETY INVITES ISRAELI ISRAEL21c has been chosen by the American Cancer Society to represent Israel at its first ACS Global Journalist Fellowship in New York City. Viva Sarah Press, associate editor at the Israeli website who formerly wrote for The Jerusalem Post, is one of 44 journalists and 78 cancer and tobacco control advocates from around the world to be invited to take part in this unique workshop from June 18 to 22. Press will be the only journalist from Israel attending.The ACS initiated the fellowship in order to generate awareness of the increasing burden of cancer around the world. The journalist fellows will attend UN meetings and meet with world-leading experts about the latest developments in cancer and tobacco control.Cancer is a leading cause of mortality worldwide. In 2007, it accounted for 7.9 million deaths, around 13% of all deaths, according to figures from the World Health Organization (WHO). Despite the fact that about 30% of all cancer deaths can be prevented, the mortality rate is rising. Until now heart disease was the number one killer worldwide, but experts suggest cancer deaths will soon overtake this figure. By 2030, cancer will cause an estimated 12 million deaths a year, according to WHO.Israel is a leading players in cancer research, recognized for its major contributions to the field. Over the past 10 years, ISRAEL21c has reported extensively on the many breakthroughs emerging from the country.“I am honored to be chosen to take part in this important conference,” said Press, who served as a senior news editor at IBA News, Israel’s only English-language news broadcast, for seven years before joining ISRAEL21c in January. “Cancer is a major cause of death worldwide, and it’s vital that we continue to raise awareness about this deadly disease.”
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Hebrew U scientists learn why DNA breaks down in cancer cells; American Cacner Society invites Israeli site to global fellowship.
The common denominator of all kinds of cancer cells is damage to the genes’ normal DNA. Although it is already known that cell damage is caused by stress to their DNA replication when cancerous cells invade, the molecular basis remained unclear.But now, reportedly for the first time, Hebrew University scientists have shown that in early cancer development, cells suffer from insufficient building blocks to support normal DNA replication. It is possible to halt this by externally supplying the “building blocks,” resulting in reduced DNA damage and the cells’ significantly lower liklihood of developing cancerous features. Thus, it is hoped that eventually this will provide protection against cancer development.Prof. Batsheva Kerem of the Alexander Silberman Institute of Life Sciences and her Ph.D. student Assaf Bester showed that abnormal activation of cellular proliferation that drives many different cancer types leads to insufficient levels of the DNA building blocks (nucleotides) needed to support normal DNA replication.Then, using lab cultures to which cancerous cells were introduced, the researchers were able to show that through external supply of those DNA building blocks it is possible to reactivate normal DNA synthesis, thus negating the damage caused by the cancerous cells. This work, documented in the journal Cell, raises the possibility of new approaches for protection against precancerous development, even possibly creating a kind of treatment to decrease DNA breakage.CANCER SOCIETY INVITES ISRAELI ISRAEL21c has been chosen by the American Cancer Society to represent Israel at its first ACS Global Journalist Fellowship in New York City. Viva Sarah Press, associate editor at the Israeli website who formerly wrote for The Jerusalem Post, is one of 44 journalists and 78 cancer and tobacco control advocates from around the world to be invited to take part in this unique workshop from June 18 to 22. Press will be the only journalist from Israel attending.The ACS initiated the fellowship in order to generate awareness of the increasing burden of cancer around the world. The journalist fellows will attend UN meetings and meet with world-leading experts about the latest developments in cancer and tobacco control.Cancer is a leading cause of mortality worldwide. In 2007, it accounted for 7.9 million deaths, around 13% of all deaths, according to figures from the World Health Organization (WHO). Despite the fact that about 30% of all cancer deaths can be prevented, the mortality rate is rising. Until now heart disease was the number one killer worldwide, but experts suggest cancer deaths will soon overtake this figure. By 2030, cancer will cause an estimated 12 million deaths a year, according to WHO.Israel is a leading players in cancer research, recognized for its major contributions to the field. Over the past 10 years, ISRAEL21c has reported extensively on the many breakthroughs emerging from the country.“I am honored to be chosen to take part in this important conference,” said Press, who served as a senior news editor at IBA News, Israel’s only English-language news broadcast, for seven years before joining ISRAEL21c in January. “Cancer is a major cause of death worldwide, and it’s vital that we continue to raise awareness about this deadly disease.”