Popular US television news anchor Savannah Guthrie posted an Instagram video on Monday, begging for the return of her mother and urging viewers to help. 

"We are at an hour of desperation, and we need your help," she said, as the search for 84-year-old Nancy Guthrie enters its second week.

"We believe our mom is still out there," Guthrie, host of NBC's "Today" morning show, said. "We need your help. She was taken, and we don't know where."

She asked viewers, wherever they are, to report anything suspicious to law enforcement.

The disappearance of Nancy Guthrie

Nancy Guthrie was last seen near Tucson, Arizona, on January 31, when family members dropped her off at her residence after dinner with them. Relatives reported her missing around noon the following day, according to authorities.

Pima County Sheriff Chris Nanos has described Nancy Guthrie as frail with extremely limited mobility. Nanos said she could not have left her home unassisted.

Guthrie's family and law enforcement have previously warned that the victim may be at risk without her medication. "She is without any medicine," Savannah Guthrie said in a previous announcement. "She needs it to survive. She needs it not to suffer."

Lara Sukster Mosheyoff contributed to this report.