The US military suffered no combat casualties after Iran retaliated against US-Israeli strikes with hundreds of missiles and drones, US Central Command said on Saturday.

In a released statement, CENTCOM announced that Operation Epic Fury had commenced at the direction of President Donald Trump, striking targets including IRGC command and control facilities, Iranian air defense capabilities, missile and drone launch sites, and military airfields.

Despite "hundreds of Iranian missile and drone attacks," there have been no reported US casualties or combat-related injuries, CENTCOM wrote.

A still image released by US Central Command (CENTCOM), which accompanied a press release describing the operation dubbed ''Epic Fury'', an attack by the United States and Israel on Iran, shows a rocket launch from a ship, in this picture obtained from social media released on February 28, 2026.
A still image released by US Central Command (CENTCOM), which accompanied a press release describing the operation dubbed ''Epic Fury'', an attack by the United States and Israel on Iran, shows a rocket launch from a ship, in this picture obtained from social media released on February 28, 2026. (credit: US CENTCOM via X/Handout via REUTERS)

Largest regional concentration of American military firepower

Damage to US installations was "minimal," and CENTCOM stressed that it has not impacted operations.

The statement also noted that the operation involves "the largest regional concentration of American military firepower in a generation," including precise munitions launched from air, land, and sea. CENTCOM's Task Force Scorpion Strike also employed low-cost one-way attack drones for the first time in combat.

Reuters contributed to this report.