Israeli scientists 'print' world's first 3D heart with human tissue

A team of Tel Aviv University researchers revealed the heart, which was made using a patient’s own cells and biological materials.

By
April 15, 2019 17:37
2 minute read.

3D Heart

3D Heart

 
X

Dear Reader,
As you can imagine, more people are reading The Jerusalem Post than ever before. Nevertheless, traditional business models are no longer sustainable and high-quality publications, like ours, are being forced to look for new ways to keep going. Unlike many other news organizations, we have not put up a paywall. We want to keep our journalism open and accessible and be able to keep providing you with news and analysis from the frontlines of Israel, the Middle East and the Jewish World.

As one of our loyal readers, we ask you to be our partner.

For $5 a month you will receive access to the following:

  • A user experience almost completely free of ads
  • Access to our Premium Section
  • Content from the award-winning Jerusalem Report and our monthly magazine to learn Hebrew - Ivrit
  • A brand new ePaper featuring the daily newspaper as it appears in print in Israel

Help us grow and continue telling Israel’s story to the world.

Thank you,

Ronit Hasin-Hochman, CEO, Jerusalem Post Group
Yaakov Katz, Editor-in-Chief

UPGRADE YOUR JPOST EXPERIENCE FOR 5$ PER MONTH Show me later

A team of Israeli researchers has “printed” the world’s first 3-D vascularized, engineered heart.

On Monday, a team of Tel Aviv University researchers revealed the heart, which was made using a patient’s own cells and biological material. Until now, scientists have successfully printed only simple tissues without blood vessels.

“This is the first time anyone anywhere has successfully engineered and printed an entire heart replete with cells, blood vessels, ventricles and chambers,” said Prof. Tal Dvir of TAU’s School of Molecular Cell Biology and Biotechnology, Department of Materials Science and Engineering in the Center for Nanoscience and Nanotechnology, and the Sagol Center for Regenerative Biotechnology, who was the lead researcher for the study.

He worked with Prof. Assaf Shapira of TAU’s Faculty of Life Sciences, and Nadav Moor, a doctoral student. Their research was published in Advanced Science.

Heart disease is the leading cause of death among both men and women in the United States. In Israel, it is the second largest cause of death (after cancer). In 2013, heart disease accounted for about 16% of the total number of deaths in Israel, according to the Health Ministry.

Heart transplantation is often the only treatment available to patients with end-stage heart failure. The waiting list for patients in the US can be as much as six months or more. In Israel and the US, many patients die while on the waiting list, hoping for a chance at survival.

“This heart is made from human cells and patient-specific biological materials. In our process, these materials serve as the bio-inks, substances made of sugars and proteins that can be used for 3-D printing of complex tissue models,” Dvir explained.


“People have managed to 3D-print the structure of a heart in the past, but not with cells or with blood vessels. Our results demonstrate the potential of our approach for engineering personalized tissue and organ replacement in the future,” he said.

At this stage, the 3-D heart produced at TAU is sized for a rabbit, but the professors said that larger human hearts could be produced using the same technology.

For the research, a biopsy of fatty tissue was taken from patients, according to a release. The cellular and a-cellular materials of the tissue were then separated. The cells were reprogrammed to become pluripotent stem cells that could then be efficiently differentiated into cardiac or endothelial cells. The extracellular matrix (ECM), a three-dimensional network of extracellular macromolecules, such as collagen and glycoproteins, was processed into a personalized hydrogel that served as the printing “ink.” The differentiated cells were then mixed with the bio-inks and were used to 3D-print patient-specific, immune-compatible cardiac patches with blood vessels and, subsequently, an entire heart.

According to Dvir, the use of “native” patient-specific materials is crucial to successfully engineering tissues and organs.

The next step, they said, is to teach the hearts to behave like human hearts. First, they will transplant them into animals and eventually into humans. The hope is that within “10 years, there will be organ printers in the finest hospitals around the world, and these procedures will be conducted routinely,” Dvir said.

Join Jerusalem Post Premium Plus now for just $5 and upgrade your experience with an ads-free website and exclusive content. Click here>>

Related Content

Romi Gouves and Nevo Almalem, creators of the Clanz project, win the Glickman Prize.
May 21, 2019
Technology to prevent abuse of elderly wins $25,000 Glickman Prize

By JERUSALEM POST STAFF