A CGI animated video that depicting the assassination of former US President Donald Trump was recently posted on the account.
Isfahan, Iran’s third-largest city, has been the site of protests over water shortages in recent weeks, with hundreds of protestors on the streets.
“Khamenei is ruining lives and dreams for his hatred towards Jewish people and the Jewish State of Israel.”
One youth was shot dead with pellet guns in street protests over water shortages. At least one policeman and three young men had been shot dead in earlier protests.
Some protests in Iran against power shortages turned political, with chants of "Death to the dictator" and "Death to Khamenei."
TV showed Khamenei, 82, receiving what it said was the COVIran Barakat vaccine, developed by a state-affiliated conglomerate and approved for public use earlier this month.
A mark of his campaign has been Iranian self-resilience and the “resistance economy” having the ability to overcome American sanctions.
For nearly two decades now, two factors have been affecting political analyses in the West about Iranian politics; reformists and an imminent death of Khamenei.
Tehran has returned to its earliest position that the US must make all concessions in lifting sanctions first, with it only ceasing nuclear violations afterward.
Khamenei was speaking on Iran's annual Quds Day, which uses the Arabic name for Jerusalem, held on the last Friday of the Muslim fasting month of Ramadan.