Operating autonomously, the spacecraft began its departure with a 90-minute fly-around of the space station as the crew snapped a series of survey photographs of the orbiting outpost.
SpaceX supplied the spacecraft, launched it from Florida and flew it from the company's suburban Los Angeles headquarters.
Their return marked the end of the first crew rotation mission to the station by the Crew Dragon spacecraft.
Musk won. Bezos was not happy.
The helmeted astronauts, dressed in their custom white flight suits and black boots, walked out of the space center's operations building a little over three hours prior to launch time, waving to onlookers and bidding goodbye to loved ones.
The crew will live aboard the US segment of the ISS for about eight days and participate in research and philanthropic projects.
SpaceX’s Crew Dragon capsule, dubbed Resilience by its crew of three Americans and one Japanese astronaut, docked 27 hours after launching atop a Falcon 9 rocket from Cape Canaveral.