Technion biologists offer a new strategy to combat the HIV-1 virus

Assistant Prof. Akram Alian said on Sunday that due to the partial failure of existing drugs, the strategy of medical research in this field is changing.

August 2, 2015 17:12
2 minute read.
Assistant Prof. Akram Alian

Assistant Prof. Akram Alian. (photo credit: TECHNION)


Dear Reader,
As you can imagine, more people are reading The Jerusalem Post than ever before. Nevertheless, traditional business models are no longer sustainable and high-quality publications, like ours, are being forced to look for new ways to keep going. Unlike many other news organizations, we have not put up a paywall. We want to keep our journalism open and accessible and be able to keep providing you with news and analysis from the frontlines of Israel, the Middle East and the Jewish World.

As one of our loyal readers, we ask you to be our partner.

For $5 a month you will receive access to the following:

  • A user experience almost completely free of ads
  • Access to our Premium Section
  • Content from the award-winning Jerusalem Report and our monthly magazine to learn Hebrew - Ivrit
  • A brand new ePaper featuring the daily newspaper as it appears in print in Israel

Help us grow and continue telling Israel’s story to the world.

Thank you,

Ronit Hasin-Hochman, CEO, Jerusalem Post Group
Yaakov Katz, Editor-in-Chief


Biologists at Haifa’s Technion-Israel Institute of Technology have offered a new strategy to combat the HIV-1 virus that causes AIDS.

Asst.-Prof. Akram Alian said on Sunday that due to the partial failure of existing drugs, the strategy of medical research in this field is changing. “Instead of focusing on the proteins of the virus and the development of drugs that target them, the new strategy focuses on the interactions of the virus proteins with the host cell. This strategy is far more effective, since the virus cannot survive and reproduce without relying on the cellular mechanisms of the host cell,” he said.

The AIDS epidemic continues to take the lives of millions around the world, he said. Despite the resistance of the body cells that are attacked, and despite the use of dedicated drugs, HIV-1 virus manages to survive and reproduce in the living cell and is displaying increasing resistance.

However, the new strategy also has its weaknesses. Alian explained that “when the virus encounters a barrier on its way into a cell, it looks for ‘detours’ that will enable it to take advantage of the cell nevertheless. Since there is redundancy in the host cell – various mechanisms leading to the same operation – the virus may exploit a self-mutation” that could enable it to make use of that detour.

“Our hypothesis is that the redundancy in the cellular pathways may represent a survival mechanism that allows the virus to take advantage of a wide variety of similar processes,” said Alian. “The virus can use these detours when the favored route is blocked by natural cellular mechanisms or artificial drugs and under other circumstances in which it is better for the virus to circumvent the obstacles of the cellular environment and the various stages of replication.”

Alian and his research assistant Dr. Ailie Marx published an abstract of their concept in a paper published in a recent issue of the Journal of Virology .

A previous article, published in the journal Cell Structure in October 2014, reviewed a new approach to AIDS research developed by scientists at Alian’s laboratory. The researchers conducted a comparison of an import - ant viral protein (integrase) that exists in both HIV-1 and FIV – the AIDS pathogen in cats – and discovered new differences that could aid in the understanding and prediction of the development of resistance. With both viruses, the integrase inserts the viral DNA into the DNA of the infected cell, and then replicates itself in a manner that enables it to spread through - out the body.

“The virus is a kind of Trojan horse, which uses the host’s genome in order to replicate,” explained Alian. “Now we are studying this issue in depth and trying to develop this idea of ‘multiple route reproduction of the HIV virus,’ as a new strategy in the treatment of AIDS.”

Join Jerusalem Post Premium Plus now for just $5 and upgrade your experience with an ads-free website and exclusive content. Click here>>

Related Content

April 19, 2019
Hillel's tech corner: Early Detection Saves Lives