Images of mouse cochlea 311.
(photo credit: PLoS Biology )
Providing clues to deafness, researchers at Washington
University School of Medicine in St. Louis have identified a gene that
is required for proper development of the mouse inner ear.
humans, this gene, known as FGF20, is located in a portion of the genome
that has been associated with inherited deafness in otherwise healthy
“When we inactivated FGF20 in mice, we saw they were
alive and healthy,” says senior author David M. Ornitz, MD, PhD, the
Alumni Endowed Professor of Developmental Biology. “But then we figured
out that they had absolutely no ability to hear.”
The results, published online Jan. 3 in PLoS Biology
show that disabling the gene causes a loss of outer hair cells, a
special type of sensory cell in the inner ear responsible for amplifying
sound. While about two-thirds of the outer hair cells were missing in
mice without FGF20, the number of inner hair cells, the cells
responsible for transmitting the amplified signals to the brain,
“This is the first evidence that inner and outer
hair cells develop independently of one another,” says first author
Sung-Ho Huh, PhD, postdoctoral research associate. “This is important
because most age-related and noise-induced hearing loss is due to the
loss of outer hair cells.”
As such, Ornitz and Huh speculate that FGF20 signaling will be a
required step toward the goal of regenerating outer hair cells in
mammals, the only vertebrates incapable of such feats of hearing
“Birds and, in fact, all vertebrates other than mammals have the ability
to regenerate hair cells,” says co-author Mark E. Warchol, PhD,
professor of otolaryngology. “Understanding how mammals differ from the
rest is a topic of great interest.”
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The FGF20 gene codes for one member of a family of proteins known as
fibroblast growth factors. In general, members of this family are known
to play important and broad roles in embryonic development, tissue
maintenance and wound healing.
Beyond a simple on and off switch, Ornitz and his colleagues found that
FGF20 signaling (or its chemical equivalent, FGF9) must occur on or
before day 14 of the embryo’s development to produce a normal inner ear.
Even if FGF20 or FGF9 signaling occurred on day 15 or later, the inner
ear still did not develop properly.
“In mice, the precursor cells that can become outer hair cells must be
exposed to the FGF20 protein at an early stage,” Ornitz says. “After
embryonic day 14, it doesn’t matter if they see the protein. It’s too
late for them to become outer hair cells.”
This critical time point does not exist in other vertebrates that retain
the ability to form new hair cells throughout their lives. Whether
FGF20 plays a role in this regeneration remains an open question.
“We’re literally doing those experiments right now,” Warchol says. “But
FGF20 has been shown to be involved in other kinds of regeneration like
the regrowth of zebrafish fins.”
Ornitz and his colleagues also see evidence that mutations in FGF20 may
play a role in human deafness. A genetic region known as DFNB71 has been
associated with congenital deafness in a few human families.
“And FGF20 is right smack in the center of that region,” Ornitz says.
“Based on our work, we are predicting that these families will have some
sort of mutation in the FGF20 gene. It hasn’t been found yet, but a
group at the Baylor College of Medicine is sequencing this region of the
genome to look for FGF20 gene mutations.”
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