Link found between brain region for taste memory and region that encodes time, place of tasting

“This means that even during a simple associative taste, the brain operates the hippocampus to produce an integrated experience," researcher says.

September 22, 2014 18:20
3 minute read.
Yellow basmati rice

Yellow basmati rice mixes a savory taste with a sweet one by adding green raisins.. (photo credit: YAKIR LEVY)

If you have ever eaten something completely new that made you sick, don’t give up. If you taste the same food in a different place, your brain will be more “forgiving” of the new attempt, according to a new study by neurobiologists at the University of Haifa.

Doctoral student Adaikkan Chinnakkaruppan and colleagues in the laboratory of Prof. Kobi Rosenblum in the department found for the first time that there is a link between the areas of the brain responsible for taste memory in a negative context and those areas in the brain responsible for processing the memory of the time and location of the sensory experience. When we experience a new taste without a negative context, this link doesn’t exist, the Ph.D. student said.

The area of the brain responsible for storing memories of new tastes is the taste cortex, found in a relatively insulated area of the human brain known as the insular cortex. The area responsible for formulating a memory of the place and time of the the episode is the hippocampus.

Until now, researchers assumed that there was no direct connection between these areas -- that the processing of information about a taste is not related to the time or the place one experiences the taste. The accepted thinking was that a negative experience – for example, being exposed to a bad taste – would be negative in the same way anywhere, and the brain would create a memory of the taste itself, disconnected from the time or place.

But in this new study, carried out in cooperation with the Riken Institute (Tokyo’s leading brain research institute) and recently published in the Journal of Neuroscience, the researchers showed for the first time that there is a functional link between the two brain regions.

In the study, the researchers sought to examine the relationship between the taste cortex (responsible for taste memory) and three different areas in the hippocampus: CA1 (which is responsible for encoding the concept of space, meaning where we are located); DG (the area responsible for encoding the time relationship between events); and CA3 (responsible for filling in missing information). To do this, the team took ordinary mice and mice that were genetically engineered by their Japanese colleagues such that these three areas of the brain functioned normally but were lacking plasticity, which did not allow new memories reliant on them to be created. The findings exposed the complexity and richness of the simple sensory experiences that are engraved in our brains and that in most cases, we are unaware of them.

“In brain research, the manipulation we do must be very delicate and precise, otherwise the changes can make the entire experiment irrelevant to proving or refuting the research hypothesis,” said Rosenblum.

The mice were exposed to two new tastes, one that caused stomach pains (to mimic exposure to toxic food) and another that didn’t cause that feeling. By comparing the two groups, it emerged that when the new taste was not accompanied by an association with toxic food, there was no difference between the normal mice and those whose various functional areas in the hippocampus didn’t allow plasticity. But when the taste caused a negative feeling, there was clear involvement of the CA1 area.

“The significance of this is that the moment we go back to the same place at which we experienced the taste associated with a bad feeling, subconsciously the negative memory will be much stronger than if we come to taste the same taste in a totally different place,” explained Rosenblum. Similarly, the DG area was involved the more time that passed between the new taste and the stomach discomfort.

“This means that even during a simple associative taste, the brain operates the hippocampus to produce an integrated experience that includes general information about the time between events and their location,” he concluded.

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