Iran-backed militants targeted the US military's Green Village base in Syria in retaliation after violence arose between the militants and US armed forces.
A foreign ministry statement specifically referred to Israeli air raids on Tuesday on Aleppo International Airport which damaged the runway and put the site out of service.
Israel has long seen its foe Iran's deepening entrenchment in Syria as a national security threat and is widening the scope of its strikes to hit at this new transport method.
An air strike hit a neighborhood right near a hospital in the capital of Tigray region.
Syrian air defenses confronted an "Israeli aggression" over the Masyaf area in Hama countryside, Syrian state media reported on Friday.
The Israeli airstrikes were the most severe since 2006 and came after the IDF fired some 100 artillery shells towards south Lebanon.
The United States told the UN Security Council on Tuesday that it targeted Iran-backed militia in Syria and Iraq with airstrikes.
US Ambassador to the United Nations, Linda Thomas-Greenfield, said the airstrikes hit facilities used by militia blamed for an escalating series of drone and rocket attacks against US personnel.
The discourse, which without irony uses the rhetoric of human rights to undercut international law, diverts attention from the incontrovertibly illegal attacks by Hamas on Israel.
If carried out by Israel the strike was rare in that it took place during the day, likely a sign that whatever was attacked was of high value.
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