Syrian air defenses shot down a number of missiles, state media said, without giving details on the targets hit.
As of Monday morning, the coalition had not issued a statement about the strikes.
The IDF targeted military headquarters, infrastructure, and outposts belonging to the terrorist group Hezbollah.
Kanaani said the US attacks were designed "to overshadow the Zionist regime's crimes in Gaza." He did not indicate if Iran would take any action in response.
Syrian state media said only material damage was caused by the airstrikes.
The brigade raided terrorist hubs in the western portion of Khan Yunis, successfully killing numerous Hamas and PIJ fighters, destroying terror infrastructure, and locating many weapons.
The terrorist group says they will continue to fight US troops in Iraq until the US leaves Iraq. “Our jihad operations against the American invaders will continue until their last soldier leaves."
The US strikes are the latest against the Iran-backed group over its targeting of Red Sea shipping, and followed a larger round of strikes a day earlier.
Syrian state media said a likely Israeli attack had targeted a building in the Mazzeh neighborhood of Damascus, without giving further details.
The US military carried out retaliatory air strikes in Iraq after a drone attack earlier by Iran-aligned terrorists that left one US service member in critical condition, and two others wounded.