Israeli researchers find first biological link between stress and obesity

Although intuitively we assume that these two phenomena overlap, the link has never been proven scientifically.

By JUDY SIEGEL-ITZKOVICH
The Hebrew University (photo credit: Wikimedia Commons)
The Hebrew University
(photo credit: Wikimedia Commons)
A connection between anxiety and metabolic disorders at the molecular level has been discovered for the first time by Hebrew University researchers, opening up new possibilities for detecting and treating both symptoms. The study has just been published in the journal Trends in Molecular Medicine.
 
Metabolic and anxiety-related disorders both pose a significant healthcare burden and are in the spotlight of contemporary research and therapeutic efforts, said Prof. Hermona Soreq from the university’s Edmond and Lily Safra Center for Brain Sciences who headed the team. Although intuitively we assume that these two phenomena overlap, the link has never been proven scientifically.
 
Now, Soreq and her colleagues have found the molecular elements that bridge anxiety and metabolism – a type of microRNA that influences shared biological mechanisms.
 
Metabolic disorders, such as abdominal obesity and diabetes, have become a global epidemic. In the US alone, the prevalence of metabolic syndrome is as high as 35%. In other countries, such as Austria, Denmark and Ireland, it affects 20% to 25% of the population, and in Israel, it is similar.
 
Anxiety disorders are harder to quantify than metabolic ones. They include obsessive-compulsive disorder (OCD), post-traumatic stress disorder (PTSD) and phobias. The full burden of the anxiety spectrum is difficult to assess, due to under-diagnosis and poorly defined patho-physiological processes.
 
This newly revealed link offers novel opportunities for innovative diagnoses and treatment of both metabolic and anxiety-related phenomena, Soreq said.
 
“We already know that there is a connection between body and mind, between the physical and the emotional, and studies show that psychological trauma affects the activity of many genes. Our previous research found a link between microRNA and stressful situations. Stress and anxiety generate an inflammatory response and dramatically increase the expression levels of microRNA regulators of inflammation in both the brain and the gut -- for example the situation of patients with Crohn’s disease may get worse under psychological stress,” said Soreq.
 
“In the present study, we added obesity to the equation. We revealed that some anxiety-induced microRNA are not only capable of suppressing inflammation but can also potentiate metabolic syndrome-related processes. We also found that their expression level is different in diverse tissues and cells, depending on heredity and exposure to stressful situations,” she explained.
 
The family of microRNA genes is part of the human genome, which was considered until not too long ago as “junk DNA.”  But, microRNAs are now known to carry out an important role in regulating the production process of proteins by other genes. These tiny RNA molecules, which are one percent of the average size of a protein-coding gene, act as suppressors of inflammation and are able to halt the production of proteins.
 
The research paper, details the evidence linking microRNA pathways, which share regulatory networks in metabolic and anxiety-related conditions. In particular, microRNAs involved in these disorders include regulators of acetylcholine signaling in the nervous system and their accompanying molecular machinery.
 
“The discovery has a diagnostic value and practical implications, because the activity of microRNAs can be manipulated by DNA-based drugs,” concluded Soreq. “It also offers an opportunity to reclassify ‘healthy’ and ‘unhealthy’ anxiety and metabolic-prone states, and inform putative strategies to treat these disorders.”