British researchers have mapped the parts of the brain that support our ability to solve problems without prior experience – otherwise known as fluid intelligence, which is the defining feature of human cognition.
Fluid intelligence predicts educational and professional success, social mobility, health and longevity, and also correlates with many cognitive abilities such as memory.
It is thought to be a key feature involved in “active thinking” – a set of complex mental processes such as those involved in abstraction, judgment, attention, strategy generation and inhibition. These skills can all be used in everyday activities, from organizing a dinner party to filling out a tax return.
Despite its central role in human behavior, fluid intelligence remains contentious regarding whether it is a single cognitive ability or a cluster of them, and the nature of its relationship with the brain.
How was the study conducted?
To establish which parts of the brain are necessary for a certain ability, researchers must study patients in whom that part is either missing or damaged. Such “lesion-deficit mapping” studies are difficult to conduct due to the challenge of identifying and testing patients with focal brain injury. As a result, previous studies have mainly used functional imaging (fMRI) techniques that can be misleading.
The new study, led by researchers at the Queen Square Institute of Neurology at University College London and its National Hospital for Neurology and Neurosurgery, was published in Brain under the title “Graph lesion-deficit mapping of fluid intelligence.”
The team investigated 227 patients who had suffered either a brain tumor or stroke to specific parts of the brain, using the Raven Advanced Progressive Matrices (APM) – the best established test of fluid intelligence. It contains multiple-choice visual pattern problems of increasing difficulty. Each problem presents an incomplete pattern of geometric figures and requires the selection of the missing piece from a set of possible choices. The researchers then introduced a novel “lesion-deficit mapping” approach to disentangle the intricate anatomical patterns of common forms of brain injury such as stroke.
Their approach treated the relationship between brain regions as a mathematical network whose connections describe the tendency of regions to be affected together, either because of the disease process or in reflection of common cognitive ability.
This helped the researchers to disentangle the brain map of cognitive abilities from the patterns of damage, allowing them to map the different parts of the brain and determine which patients did worse in the fluid intelligence task according to their injuries.
What were the study's conclusions?
They found that fluid intelligence-impaired performance was largely confined to patients with right frontal lesions, rather than a wide set of regions distributed across the brain. Alongside brain tumors and stroke, such damage is often found in patients with a range of other neurological conditions, including traumatic brain injury and dementia.
“Our findings indicate for the first time that the right frontal regions of the brain are critical to the high-level functions involved in fluid intelligence, such as problem-solving and reasoning,” Lead author Prof. Lisa Cipolotti said. This supports the use of APM in a clinical setting, as a way of assessing fluid intelligence and identifying right frontal lobe dysfunction.
“Our approach of combining novel lesion-deficit mapping with a detailed investigation of APM performance in a large sample of patients provides crucial information about the neural basis of fluid intelligence,” she said. “More attention to lesion studies is essential to uncover the relationship between the brain and cognition, which often determines how neurological disorders are treated.”