For most people, coffee is perceived as a natural stimulant, one that sharpens concentration, reduces fatigue and makes it possible to function better during the day. However, precisely among people with Attention Deficit Hyperactivity Disorder, surprising reports are heard again and again: Caffeine has almost no effect, and sometimes even causes a feeling of calmness or drowsiness. This phenomenon is described consistently in medical reports, in clinics and on leading health websites, and is generating increasing interest among doctors and researchers alike.

To understand the seemingly unusual situation, it is important to understand how caffeine works in most of the population. Caffeine is a well-known psychoactive substance that works mainly by blocking adenosine receptors in the brain. Adenosine is a substance that accumulates during waking hours and contributes to the feeling of fatigue. When caffeine blocks these receptors, the feeling of fatigue decreases, and at the same time the activity of neural systems associated with alertness increases, including the dopamine and norepinephrine systems. Among people without Attention Deficit Hyperactivity Disorder, this combination is usually translated into an increase in concentration, alertness and the feeling of energy.

However, in ADHD the neurological starting point is different. Attention Deficit Hyperactivity Disorder is described in medical reports as a neurodevelopmental disorder in which there is unbalanced activity of neurotransmitters, mainly dopamine and norepinephrine, in areas responsible for attention, self-regulation and cognitive control. The common prescription medications for Attention Deficit Hyperactivity Disorder act in a targeted way on these systems and increase the availability of those substances in a controlled manner.

Attention Deficit Hyperactivity Disorder
Attention Deficit Hyperactivity Disorder (credit: SHUTTERSTOCK)

Caffeine, on the other hand, works in a more general way. Leading health websites and clinical reports note that among some people with ADHD, blocking adenosine does not create a clear stimulating effect, but rather a regulating effect. Instead of increasing activity, caffeine may reduce the feeling of internal noise, mental restlessness and the sense of overload. For some patients, the decrease in cognitive load is translated into a feeling of calmness, and sometimes even fatigue.

Doctors and clinicians who specialize in Attention Deficit Hyperactivity Disorder describe this phenomenon in clinical reports and review articles as a response that is not rare. Patients report that they can drink coffee before going to sleep without experiencing difficulty falling asleep, or that they feel quiet concentration but without a sense of physical awakening. It is important to emphasize: This is not a uniform response. There are people with ADHD who respond to caffeine in a similar way to the general population, but others experience a completely different effect.

Medical health websites emphasize that caffeine is not considered a treatment for Attention Deficit Hyperactivity Disorder and is not recommended as a substitute for dedicated medications. Reports from clinics indicate that its effect is weak and unpredictable, and sometimes even accompanied by side effects such as anxiety, a rapid pulse or sleep disturbances, especially at high doses. Because of this, the use of caffeine is considered at most a secondary factor, and not a therapeutic tool.

Illustration: Sleeping disorder
Illustration: Sleeping disorder (credit: INGIMAGE)

The practical question that arises from the field is how people with ADHD can cope with fatigue during the day if coffee does not provide the expected effect. Doctors note in medical reports that fatigue in Attention Deficit Hyperactivity Disorder is not always caused only by lack of sleep, but also by ongoing cognitive effort, sensory overload and difficulty regulating attention over time. Therefore, the recommended solutions do not focus only on caffeine.

The recommendations include maintaining regular sleep, exposure to natural light in the morning hours, short physical activity during the day and planned breaks from prolonged tasks. Accurate adjustment of medication treatment, when it is given, may also improve alertness and reduce fatigue. Clinical reports emphasize that when treatment is properly adjusted, the need to rely on caffeine decreases.

The conclusion emerging from the medical reports is clear. Caffeine does not act uniformly on everyone, and among some people with Attention Deficit Hyperactivity Disorder it may not stimulate at all, and sometimes may even calm. This is a recognized response documented in clinical reports, and not an exceptional deviation. For people with ADHD who feel that coffee simply does not “work” on them, the explanation is not psychological or imaginary, but rooted in the way their brain processes stimuli.

Dr. Itay Gal is a specialist in pediatrics, a sports and aviation physician, and a researcher of infectious diseases. The health correspondent and medical commentator of Maariv and a lecturer in the fields of medicine and innovation. For more articles click here.