The United States hopes talks with Iran in Geneva on Thursday will produce an agreement to end or reduce Iran’s nuclear-weapons program substantially below what it was coming out of the 2015 Obama-era nuclear deal and to reduce the threat of Tehran’s ballistic-missile program.

US President Donald Trump has amassed the largest buildup of American forces in the Middle East since 2003 to increase pressure on the Islamic Republic to reach a deal, with the open question being whether the two sides’ redlines can overlap just enough to avoid a broader war.

Israel would only support a deal that neutralizes both the nuclear and ballistic missile threats, whereas Trump has signaled a readiness to reach a deal even if he achieves less than fully neutralizing those threats, especially regarding ballistic missiles, as long as he can portray his achievements as being far beyond Obama’s.

What is at stake?

Iran has, over the decades, developed an advanced and large-scale uranium-enrichment program. While enriched uranium can be used as fuel in power plants at various purity levels, at high levels, it can be used to make nuclear weapons.

USS Gerald R. Ford aircraft carrier leaves Souda Bay on the island of Crete, Greece, February 26, 2026
USS Gerald R. Ford aircraft carrier leaves Souda Bay on the island of Crete, Greece, February 26, 2026 (credit: REUTERS/Makis Kartsonakis)

Until Israel and the US attacked its nuclear facilities last June, Iran was enriching uranium to up to 60% purity, a short step from the roughly 90% that is weapons-grade.

It had enough material enriched to that level, if enriched further, for 10 nuclear weapons, according to an International Atomic Energy Agency yardstick, and more at lower levels.

That material is one of the few elements of the nuclear program that was not destroyed last year, with virtually the entire fleet of 20,000 uranium-enrichment centrifuges damaged, all weapons-program items damaged, and most of the top nuclear scientists killed.

Iran has yet to declare what happened to its enriched uranium or allow the IAEA nuclear watchdog agency to inspect its bombed nuclear facilities. Israeli officials, however, have said they know the whereabouts of the enriched uranium, and other sources have indicated that most or all of the uranium was buried under rubble from the nuclear sites bombed in June 2025.

What do both sides want?

Enrich elsewhere: In previous rounds of talks, the idea was floated of a regional enrichment consortium, which would involve setting up a joint venture outside Iran with one or more other countries from the Middle East. To date, Tehran has always rejected that as an alternative to enriching on its soil.

Enrich to a low level: It becomes exponentially easier to enrich to a weapons-grade level the more highly enriched uranium you start with. In terms of effort, once you have enriched to 5% purity, you are more than halfway to weapons grade.

Keeping Iran at arm’s length from being able to race toward nuclear weapons will involve limiting the purity it can enrich to and how much enriched uranium it can amass.

The 2015 deal let Iran enrich to 3.67% purity. Diplomats have said only half-jokingly that Trump’s rejection of that deal is so great that 3.67% is the one enrichment level he will not accept now.

The latest leaks have indicated that Iran is prepared to commit to zero enrichment for some period of years, with negotiations between Tehran and Washington about whether that period would be for three, five, seven, or 10 years.

Even after that period, the Trump administration would demand enrichment at some level below 3.67%.

Iran has demanded that it not give up the right to enrich, but it showed greater readiness regarding limits, especially since it currently lacks the machines to enrich uranium.

If Trump agreed to allow such a deal, the US would likely demand far more invasive IAEA inspections than previously existed to ensure the regime’s compliance.

Alternatively, Trump may decide that absent an end to enrichment, he prefers to attack Iran.

An Iranian newspaper with a cover photo of US President Donald Trump delivering the State of the Union address, in Tehran, Iran, February 26, 2026 (credit: MAJID ASGARIPOUR/WANA
An Iranian newspaper with a cover photo of US President Donald Trump delivering the State of the Union address, in Tehran, Iran, February 26, 2026 (credit: MAJID ASGARIPOUR/WANA (WEST ASIA NEWS AGENCY) VIA REUTERS)

What else needs to be addressed?

Any deal would also have to require a thorough accounting of Iran’s stock of enriched uranium. Any doubts about that could trigger a new conflict.

As in 2015, a deal would most likely require the dilution or removal of enriched uranium and limit the number of centrifuges and where they can be used.

Little has been discussed about ballistic missiles.

The US, at a minimum, would likely want Iran to stop activities that could lead to developing intercontinental ballistic missiles (ICBMs) that could potentially strike the continental US.

Israel wants the range of ballistic missiles to be cut to below 1,000 kilometers so that they will no longer be able to reach the Jewish state.

Alternatively, Jerusalem wants to preserve its right to strike Iran's the ballistic-missile program – even if the US promises it will not strike – in the even that it is not sufficiently curbed to avoid threatening Israel.
Reuters contributed to this story.

Reuters contributed to this story.