Tehran's influence has grown since it began supporting President Bashar al-Assad in the civil war that started in 2011.
Syrian state media reported earlier on Wednesday that the country's air defenses had intercepted "hostile targets" over Homs, without giving further details.
One person is reported dead according to a Syrian human rights organization based in the UK.
Initial reports indicated that several people were injured in the alleged Israeli airstrikes.
An alleged Israeli airstrike on the Iranian consulate building in Damascus Monday night resulted in the killing of a number of Iranian Revolutionary Guard and Quds Force generals.
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Iranian media reports said Colonel Reza Zarei was killed along with two fighters from Lebanon's Iran-backed Hezbollah group.
The strikes come just days after alleged Israeli airstrikes targeted sites in Homs in central Syria.
Syrian air defenses shot down a number of missiles, state media said, without giving details on the targets hit.
Syrian state media said only material damage was caused by the airstrikes.